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The Whitening Pills - Comparison

I decided to make a comparison between all the various whitening pills esp in the aspect of ingredients.

As I am taking Lucent currently to try up the effectiveness.......


My 2 boxes of Lucent. Got it from a registered clinic in KL. Don't get cheated by the photo, the boxes are cute and tiny actually.

Both Lucent and Crystal Tomato boxes side by side.


According to the claimed by Lucent and EstheWhite, the PhytoflORAL tomato powder is the 3rd generation of Crystal Tomato carotenoid powder, which means their ingredient is much potent even though in a lower dosage.


This the TABLE i make for all few types of whitening pills available in Malaysia 's Clinic. All these medication are marketed through registered clinic. So if you got from unknown seller / online / non clinic centre, kindly question the source.


The ingredient in Crystal Tomato
 The ingredient in Lucent

I had never took EstheWhite before and can't find a photo with the actual ingredient of that product. If I have chance to try in future i will upload here k.



Here's the comparison for those Japanese brand whitening product, most of the product contains high dose of Vitamin C and L-Cysteine - at least double the dosage! However actually i do read from somewhere that L-Cysteine is actually of no use in whitening effect.



CHOCOLA BB Lucent C

The ingredients in Japanese

TRANSINO White C
The ingredients in Japanese

FANCL White Force

The down side of those Japanese brand whitening pill is that, you need to consume many tablets for the optimal effect.

For me, I think as long as the product is safe and able to deliver optimal result, with supplement in the product, then it's safe to take for long term. Another thing to consider is the price, for me Lucent's price range still acceptable. Hope can see a good result by then.

Till then.

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The Whitening Pills - FANCL White Force

FANCL WHITE FORCE 

FANCL White Force helps to protect the skin from UV Damage and accelerates the regeneration of skin cells and brings out a natural healthy glow.

Ingredients/Per 6 tablets:
Hydroxytyrosol: 20mg,
L- cystine: 240mg,
artichoke extract powder: 100mg,
Niacin: 15mg,
Vitamin C: 300mg
 Hydroxytyrosol and L-cystine rejuvenates skin from the inside. 
Artichoke extract, Vitamin C and Niacin whitens the skin and controls skin pigmentation and lighten existing pigmentation.

 Do not use when pregnant or breast feeding. Not suitable for children


Daily Intake: 6 Tablets (2 Tablets x 3 times)  
30days/180 tablets
Made in Japan

Disclaimer: Most of the product information from the product website.

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The Whitening Pills - Transino White C

TRANSINO White C

Relieves spots, freckles and pigmentation caused by sun exposure or rash

Six tablets contain the following ingredients
Ascorbic acid (vitamin C) 1000 mg
L-cysteine 240 mg
d-alpha-tocopheryl succinate (natural type vitamin E) 50 mg
Riboflavin (vitamin B2) 6 mg
Pyridoxine hydrochloride (vitamin B6) 12 mg
Other ingredients: Corn starch, lactose, cellulose, CMC, hydroxypropyl cellulose, magnesium stearate, hypromellose, (partially saponified) polyvinyl alcohol, titanium oxide, talc, soya lecithin, carnauba wax .

Indications
○ Relief of the following symptoms: Spots, freckles and pigmentation due to sun exposure or rash
○ Bleeding prophylaxis in the following situations: Gingival bleeding and epistaxis
○ Supply of Vitamin C in the following situations: Physical fatigue, pregnancy/lactation period, decline of physical strength during or after illness, and old age
Take the following amount with cold or warm water.

Age Adults (15 years or over)
Daily dose  3 tablets Twice a day in the morning and evening.
(1) Follow the Dosage and Administration strictly. (2) Use for children aged 7 or over should be supervised by guardians.

This product is a slightly orangish white to white film-coated tablet.

Taking this product may affect the results of laboratory tests performed on the urine or feces. If you are examined by doctors, tell them that you are taking a medicine containing Vitamin C. (2) The riboflavin (vitamin B2) contained in this product may turn the urine yellow.

Disclaimer: Most of the product information from the product website.

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The Whitening Pills - Chocola BB Lucent C

CHOCOLA® BB Lucent C
- for Blemishes and Brown Spots on Skin



The CHOCOLA BB series is designed to provide support for women's beauty and wellness through a number of products, such as CHOCOLA BB PLUS® for treating acne and other skin troubles. The new CHOCOLA® BB Lucent C helps whiten blemishes and brown spots on skin, two of the most common skin problems for women, and the introduction of the product will enable Eisai to respond to more diversified needs related to skin care.

It is widely believed that the oxidation in pigment cells of skin (melanocytes) causes excessive melanin production, which induces blemishes and brown spots on skin.

CHOCOLA® BB Lucent C , a pharmaceutical product which contains 600mg of vitamin C and 240mg of L-Cysteine in an adult daily dosage (6 tablets per day) promotes whitening of black-melanine with a redox action. 
Containing a large quantity of L-Cysteine compared with other L-Cysteine consumer products, the CHOCOLA® BB Lucent C treats blemishes and brown spots at subepidermal level. 
Also, natural type vitamin E, vitamin B2 and B6 have been added to improve blood flow in the epidermis and normalize skin metabolism (turnover), and eventually restore healthy skin.

Ingredients
Active Ingredients (daily dose for an adult)
Ascorbic Acid (vitamin C)...................600mg
L-Cysteine...................240mg
Vitamin B2 sodium phosphate...................15mg
Pyridoxine hydrochloride (vitamin B6)...................20mg
Acidum succinicum d-- tocopherol (natural type vitamin E) ...................100mg
Nicotinamide...................25mg
Inactive ingredients
Talc, Hydroxypropylcellulose, Titanium Oxide, Magnesium Stearate,
Microcrystalline Cellulose, Hypromellose, Macrogol

Indications
Alleviation of the following conditions: blemishes and brown spots on skin, pigmentation caused by sunburn or rush
Vitamin C supplementation in the following conditions: physical fatigue, pregnancy and nursing, recuperation during and after sickness, aging
Prevention of bleeding from the gums and nose

Dosage and administration
Tablets should be taken with cold or hot water.
For an adult (15 years old and above), take 2 tablets, three times a day, before or after meals. For a child between 7 years old and 14 years old, take 1 tablet, three times a day, before or after meals. 
When compared to the Chocola BB Plus’ main compound is Vitamin B2, Chocola BB Lucent C is a pharmaceutical product that has Vitamin C and L-cysteine as the main compounds. It softens the pigmentation resulting from freckles, spots, sunburn etc.
Chocola BB Lucent C works from inside our bodies to tackle existing skin spots or the root causes of spots, thus is recommended for anyone who wants to wants a brighten tone for their skin.

Disclaimer: Most of the product information from the product website.

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The Whitening Pills - EstheWhite & EstheShield

EstheWhite

Carotenoids are natural sun protectants found in plants. They absorb harmful UVA and UVB rays and supress free radicals that lead to premature ageing and dark, uneven skin tone. The human body is unable to produce carotenoids, but they can be obtained through diet.




EstheWhite’s key active ingredient, PhytoflORAL® is a patented innovative dietary supplement derived from a proprietary source of non-GMO tomato species that are rich in colourless carotenoids – phytoene and phytofluene. These specific carotenoids are known to lighten and even out skin tone through
  • ·         Inhibition of constitutive melanin synthesis (reduces baseline pigment production)
  • ·         Protection against UVA and UVB rays
  • ·         Significantly increasing anti-inflammatory and anti-oxidant processes

These carotenoids are truly colourless: they do not bleach nor stain the skin

An additional ingredient in EstheWhite is L-Cysteine
It has been shown to prevent the production of darker melanin, stimulate the production of glutathione, promote skin renewal and display anti-oxidant effects


In a clinical study on the effects of colorless carotenoids, clinical scoring by the dermatologist had shown that 60% to 86% of the subjects’ skin quality was significantly improved after 6 weeks and up to 90% of the subjects had improvement in skin dryness, roughness, suppleness, evenness and texture after 12 weeks. The research also showed that after 12 weeks of colorless carotenoids intake, 65% of the subjects‘ skin had a significant 20% increase in the Minimum Erythemal Dose (MED) after UV exposure testing, characterizing a photo-protective effect.

Is It Safe To Take EstheWhite?
EstheWhite is a natural food supplement, that consists of 100% non-GMO, chemically unmodified tomato powder and natural amino acids. There are no known safety concerns, however patients who are allergic or possibly allergic to tomatoes should not take it without consulting their doctor. Pregnant and breastfeeding patients are advised to consult with their obstetricians prior to commencing.

One box of EstheWhite contains 30 capsules
Each EstheWhite capsule contains 500mg of PhytoflORAL, 25mg of L-Cysteine, Cellulose, Silicon Dioxide, and Magnesium Stearate.
Take 1 capsules per day.


EstheShield

Ultimate Systemic Sun Protection
The core ingredient of EstheShield is a proven natural fern extract, polypodium leucotomos. It is an effective chemophoto-protective agent that leads to a significant decrease of UV-induced erythema, sunburn cell formation, DNA damage, epidermal hyperproliferation, and dermal mast cell infiltration.

Polypodium leucotomos has been extensively researched. Clinical studies show that polypodium extracts is effective in defending skin against damage from UV radiation when taken orally. EstheShield is a high potency formulation (500 mg) designed to provide the highest level of protection.
Polypodium leucotomos has both antioxidant and anti-inflammatory properties that help to prevent skin inflammation by inhibiting free radicals in skin tissues from causing long-term DNA damage and photo-ageing.

Is It Safe To Take EstheShield?
EstheShield has been researched for over 40 years, with an excellent safety profile. There are no known contraindications to polypodium leucotomos, however pregnant and breastfeeding patients are advised to consult with their obstetricians prior to commencing.
One box of EstheShield contains 30 capsules
Each EstheShield capsule contains 500mg of Polypodium Leucotomos, Cellulose, Silicon Dioxide, and Magnesium Stearate.
Take 1 capsules per day.


Sun Exposure and Skin Damage
Sun damage may not be visible at an early age, but multiple studies warn of the consequences later in life. Sun exposure damages fibres in the skin called elastin, resulting in skin laxity. UV rays alter the DNA, causing saggy skin, lines, wrinkles, discolouration, age spots, and even cancer.

UV radiation is composed of two different wavelengths, UVA and UVB. When the skin is exposed to UV rays, melanin is photo-oxidised (immediate pigment darkening). This is the process that darkens your skin as it attempts to block out the radiation. Prolonged or repeated exposure to UV radiation results in persistent pigment darkening and eventually long term tanning (delayed tanning) which increases both the amount and activity of melanocytes. The delayed tanning process can last 10 days to several weeks, and with repeated exposure can cause DNA photo-damage.

UVB rays cause sunburn, but it is the UVA rays, with their longer wavelength that penetrate deep into the dermis, that are responsible for photo-ageing of skin. Sensitivity to sunburn is routinely evaluated by minimal erythema dose (MED). MED describes the lowest dose (J/cm2) of UV radiation that will cause erythema assessed 24 hours after exposure. Higher MED means higher tanning capacity. Darker skin is a result of increased number of melanin: it acts a barrier to the UV radiation.

PhytoflORAL
Carotenoids are natural sun protectants found in plants. They absorb harmful UVA and UVB rays and suppress free radicals that lead to premature ageing and dark, uneven skin tone. The human body is unable to produce carotenoids, but they can be obtained through diet.

It has been shown to prevent the production of darker melanin, stimulate the production of glutathione, promote skin renewal and display anti-oxidant effects.

Clinical scoring of the skin quality was significantly improved in 60 to 86% of the panelists after 42 days and in up to 90% of the panelists after 84 days , across all parameters evaluated. Of particular interest, 95% of the subjects had improved skin evenness.

Clinical scoring by the dermatologist presents significant improvement in skin dryness, roughness, suppleness, evenness and texture. Subjective evaluation questionnaire completed by the subjects presents improvement in skin radiance, evenness, hydration, smoothness, suppleness, elasticity and irritability. 

Study subjects found their skin more resistant to sun damage, more beautiful and visibly younger and healthier
Sunlight is a source for external/topical generation of hydroxyl radicals, as was demonstrated by Taira J. et al. This group suggested that sunlight exposure of skin may lead to hydroxyl radical generation and simultaneous lipid peroxidation. Phytoene and phytofluene, the colorless carotenoids are one of the few anti-oxidants that are most effective in quenching of hydroxyl radicals (·OH) and shown in a number of publications.

Polypodium Leucotomos
The core ingredient of EstheShield is a proven natural fern extract, polypodium leucotomos. It is an effective chemophoto-protective agent that leads to a significant decrease of UV-induced erythema, sunburn cell formation, DNA damage, epidermal hyperproliferation, and dermal mast cell infiltration.The core ingredient of EstheShield is a proven natural fern extract, polypodium leucotomos.

Polypodium leucotomos has been extensively researched. Clinical studies show that polypodium extract is effective in defending skin against damage from UV radiation when taken orally. EstheShield is a high potency formulation (500 mg) designed to provide the highest level of protection.

Polypodium leucotomos has both antioxidant and anti-inflammatory properties that help to prevent skin inflammation by inhibiting free radicals in skin tissues from causing long-term DNA damage and photo-ageing.

Overall, 19 human and 6 basic science studies were included in this review spanning over 40 years of research from 1972 to 2014. Oral polypodium leucotomos was administered in daily doses ranging from 120 mg to 1080 mg. This review of literature has demonstrated that PLE is well tolerated at all doses administered.

Current level of evidence suggests that oral PLE is safe and can be prescribed confidently for long term use.
Much of the research that has been done on polypodium leucotomos over the past 40+ years has been on its management of skin conditions and its photo-protective properties after it is ingested. Many of these clinical studies have shown extracts of polypodium leucotomos to be surprisingly effective at defending skin against damage from the sun (ultraviolet radiation) when polypodium leucotomos is taken orally, with some authors even calling it an “internal sunscreen.”

A 2010 publication reported the results of a clinical trial in which 10 healthy volunteers were given either 240mg oral polypodium leucotomos 8 hours and again 2 hours before UVA exposure, or not given anything at all before UVA exposure. Prior to exposure, each individual was measured to determine his or her baseline skin histology and how much UVA radiation it took to cause erythema (MED: minimal erythema dose). After exposure, skin samples were again taken and tested for CD (common deletion: a type of DNA damage and a marker of chronic UVA radiation). At 2 times the MED the non-PL group had increases of CD of 217% over baseline, while the group taking PL had decreases of 84%. At 3 times the MED, the non-PL group had increases of CD of 760% over baseline, while the group taking PL only had a 61% increase on average. These trends were determined “very strong” by the researchers, and while the data was not statistically significant (due in part to the small sample size), the researchers concluded that Polypodium leucotomos “may prevent UVA-induced skin photodamage possibly by preventing UVA-dependent mitochondrial DNA damage.” 

In 2007, a study found that polypodium leucotomos extract was beneficial to individuals who are extremely sensitivity to the sun. The individuals all had either polymorphic light eruption (itchy red rashes from sun exposure) or solar urticaria (a form of hives caused by sunlight), but had not responded well to other available therapies. These patients’ response to sunlight was measured both before and after taking an oral dose of 480 mg of Polypodium leucotomos. The researchers reported that after taking Polypodium leucotomos and being exposed to sunlight, patients had a relevant and statistically significant reduction of skin reactions and subjective symptoms as compared to exposure without PL. The researchers concluded that the “photoprotective activity of Polypodium leucotomos was significant,” and furthermore, the tolerance of PL was excellent and administration was shown to be effective and safe. 

L-Cysteine
Glutathione, the major intracellular reductant, may become rate limiting to cytotoxic lymphocyte activation and proliferation under these circumstances. N-Acetylcysteine (NAC-cys) was used to increase intracellular glutathione levels significant changes in total glutathione (58% increase) at 96 hours. 
Glutathione acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, glutathione has a major role as a protector of biological structures and functions. 
Reactive oxygen species (ROS) are involved in various cellular events including cell proliferation, apoptosis and immune responses  L-cysteine is converted to intracellular gluthathione acting as a scavenger of ROS. 


Disclaimer: Most of the product information from the product website.

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