Carotenoids are natural sun protectants
found in plants. They absorb harmful UVA and UVB rays and supress free radicals
that lead to premature ageing and dark, uneven skin tone. The human body is
unable to produce carotenoids, but they can be obtained through diet.
EstheWhite’s key active ingredient,
PhytoflORAL® is a patented innovative dietary supplement derived from a
proprietary source of non-GMO tomato species that are rich in colourless
carotenoids – phytoene and phytofluene. These specific carotenoids are known to
lighten and even out skin tone through
- ·
Inhibition of
constitutive melanin synthesis (reduces baseline pigment production)
- ·
Protection against UVA
and UVB rays
- ·
Significantly
increasing anti-inflammatory and anti-oxidant processes
These carotenoids are truly colourless:
they do not bleach nor stain the skin
An additional ingredient in EstheWhite
is L-Cysteine.
It has been shown to prevent the
production of darker melanin, stimulate the production of glutathione, promote
skin renewal and display anti-oxidant effects
In a clinical study on the effects of
colorless carotenoids, clinical scoring by the dermatologist had shown that 60%
to 86% of the subjects’ skin quality was significantly improved after 6 weeks
and up to 90% of the subjects had improvement in skin dryness, roughness,
suppleness, evenness and texture after 12 weeks. The research also showed that
after 12 weeks of colorless carotenoids intake, 65% of the subjects‘ skin had a
significant 20% increase in the Minimum Erythemal Dose (MED) after UV exposure
testing, characterizing a photo-protective effect.
Is It Safe To Take EstheWhite?
EstheWhite is a natural food supplement, that consists of 100% non-GMO,
chemically unmodified tomato powder and natural amino acids. There are no known
safety concerns, however patients who are allergic or possibly allergic to
tomatoes should not take it without consulting their doctor. Pregnant and
breastfeeding patients are advised to consult with their obstetricians prior to
commencing.
One box of EstheWhite contains 30
capsules
Each EstheWhite capsule contains 500mg
of PhytoflORAL, 25mg of L-Cysteine, Cellulose, Silicon Dioxide, and Magnesium
Stearate.
Take 1 capsules per day.
EstheShield
Ultimate Systemic Sun Protection
The core ingredient of EstheShield is a
proven natural fern extract, polypodium leucotomos. It is an effective
chemophoto-protective agent that leads to a significant decrease of UV-induced
erythema, sunburn cell formation, DNA damage, epidermal hyperproliferation, and
dermal mast cell infiltration.
Polypodium leucotomos has been extensively
researched. Clinical studies show that polypodium extracts is effective in
defending skin against damage from UV radiation when taken orally. EstheShield
is a high potency formulation (500 mg) designed to provide the highest level of
protection.
Polypodium leucotomos has both antioxidant and anti-inflammatory properties
that help to prevent skin inflammation by inhibiting free radicals in skin
tissues from causing long-term DNA damage and photo-ageing.
Is It Safe To Take EstheShield?
EstheShield has been researched for over
40 years, with an excellent safety profile. There are no known
contraindications to polypodium leucotomos, however pregnant and breastfeeding
patients are advised to consult with their obstetricians prior to commencing.
One box of EstheShield contains 30
capsules
Each EstheShield capsule contains 500mg
of Polypodium Leucotomos, Cellulose, Silicon Dioxide, and Magnesium Stearate.
Take 1 capsules per day.
Sun
Exposure and Skin Damage
Sun damage may not be visible at an
early age, but multiple studies warn of the consequences later in life. Sun
exposure damages fibres in the skin called elastin, resulting in skin laxity.
UV rays alter the DNA, causing saggy skin, lines, wrinkles, discolouration, age
spots, and even cancer.
UV radiation is composed of two
different wavelengths, UVA and UVB. When the skin is exposed to UV rays,
melanin is photo-oxidised (immediate pigment darkening). This is the process
that darkens your skin as it attempts to block out the radiation. Prolonged or
repeated exposure to UV radiation results in persistent pigment darkening and
eventually long term tanning (delayed tanning) which increases both the amount
and activity of melanocytes. The delayed tanning process can last 10 days to
several weeks, and with repeated exposure can cause DNA photo-damage.
UVB rays cause sunburn, but it is the
UVA rays, with their longer wavelength that penetrate deep into the dermis,
that are responsible for photo-ageing of skin. Sensitivity to sunburn is
routinely evaluated by minimal erythema dose (MED). MED describes the lowest
dose (J/cm2) of UV radiation that will cause erythema assessed 24 hours after
exposure. Higher MED means higher tanning capacity. Darker skin is a result of
increased number of melanin: it acts a barrier to the UV radiation.
PhytoflORAL
Carotenoids are natural sun protectants
found in plants. They absorb harmful UVA and UVB rays and suppress free
radicals that lead to premature ageing and dark, uneven skin tone. The human
body is unable to produce carotenoids, but they can be obtained through diet.
It has been shown to prevent the
production of darker melanin, stimulate the production of glutathione, promote
skin renewal and display anti-oxidant effects.
Clinical scoring of the skin quality was
significantly improved in 60 to 86% of the panelists after 42 days and in
up to 90% of the panelists after 84 days , across all parameters
evaluated. Of particular interest, 95% of the subjects had improved skin
evenness.
Clinical scoring by the dermatologist
presents significant improvement in skin dryness, roughness, suppleness,
evenness and texture. Subjective evaluation questionnaire completed by
the subjects presents improvement in skin radiance, evenness,
hydration, smoothness, suppleness, elasticity and irritability.
Study
subjects found their skin more resistant to sun damage, more beautiful and
visibly younger and healthier
Sunlight is a source for
external/topical generation of hydroxyl radicals, as was demonstrated by Taira
J. et al. This group suggested that sunlight exposure of skin may lead to
hydroxyl radical generation and simultaneous lipid peroxidation. Phytoene and
phytofluene, the colorless carotenoids are one of the few anti-oxidants that
are most effective in quenching of hydroxyl radicals (·OH) and shown in a
number of publications.
Polypodium
Leucotomos
The core ingredient of EstheShield is a
proven natural fern extract, polypodium leucotomos. It is an effective
chemophoto-protective agent that leads to a significant decrease of UV-induced
erythema, sunburn cell formation, DNA damage, epidermal hyperproliferation, and
dermal mast cell infiltration.The core ingredient of EstheShield is a proven
natural fern extract, polypodium leucotomos.
Polypodium leucotomos has been
extensively researched. Clinical studies show that polypodium extract is
effective in defending skin against damage from UV radiation when taken orally.
EstheShield is a high potency formulation (500 mg) designed to provide the
highest level of protection.
Polypodium leucotomos has both
antioxidant and anti-inflammatory properties that help to prevent skin
inflammation by inhibiting free radicals in skin tissues from causing long-term
DNA damage and photo-ageing.
Overall, 19 human and 6 basic science
studies were included in this review spanning over 40 years of research from
1972 to 2014. Oral polypodium leucotomos was administered in daily doses
ranging from 120 mg to 1080 mg. This review of literature has demonstrated that
PLE is well tolerated at all doses administered.
Current level of evidence suggests that
oral PLE is safe and can be prescribed confidently for long term use.
Much of the research that has been done
on polypodium leucotomos over the past 40+ years has been on its management of
skin conditions and its photo-protective properties after it is ingested. Many
of these clinical studies have shown extracts of polypodium leucotomos to be
surprisingly effective at defending skin against damage from the sun
(ultraviolet radiation) when polypodium leucotomos is taken orally, with some
authors even calling it an “internal sunscreen.”
A 2010 publication reported the results
of a clinical trial in which 10 healthy volunteers were given either 240mg oral
polypodium leucotomos 8 hours and again 2 hours before UVA exposure, or not
given anything at all before UVA exposure. Prior to exposure, each individual
was measured to determine his or her baseline skin histology and how much UVA
radiation it took to cause erythema (MED: minimal erythema dose). After
exposure, skin samples were again taken and tested for CD (common deletion: a
type of DNA damage and a marker of chronic UVA radiation). At 2 times the MED
the non-PL group had increases of CD of 217% over baseline, while the group
taking PL had decreases of 84%. At 3 times the MED, the non-PL group had
increases of CD of 760% over baseline, while the group taking PL only had a 61%
increase on average. These trends were determined “very strong” by the
researchers, and while the data was not statistically significant (due in part
to the small sample size), the researchers concluded that Polypodium leucotomos
“may prevent UVA-induced skin photodamage possibly by preventing UVA-dependent
mitochondrial DNA damage.”
In 2007, a study found that polypodium
leucotomos extract was beneficial to individuals who are extremely sensitivity
to the sun. The individuals all had either polymorphic light eruption (itchy
red rashes from sun exposure) or solar urticaria (a form of hives caused by
sunlight), but had not responded well to other available therapies. These
patients’ response to sunlight was measured both before and after taking an
oral dose of 480 mg of Polypodium leucotomos. The researchers reported
that after taking Polypodium leucotomos and being exposed to sunlight, patients
had a relevant and statistically significant reduction of skin reactions and
subjective symptoms as compared to exposure without PL. The researchers
concluded that the “photoprotective activity of Polypodium leucotomos was
significant,” and furthermore, the tolerance of PL was excellent and
administration was shown to be effective and safe.
L-Cysteine
Glutathione, the major intracellular
reductant, may become rate limiting to cytotoxic lymphocyte activation and
proliferation under these circumstances. N-Acetylcysteine (NAC-cys) was used to
increase intracellular glutathione levels significant changes in total
glutathione (58% increase) at 96 hours.
Glutathione acts as a nucleophilic
scavenger and as an enzyme-catalyzed antioxidant in the event of
electrophilic/oxidative tissue injury. Therefore, glutathione has a major role
as a protector of biological structures and functions.
Reactive oxygen species (ROS) are
involved in various cellular events including cell proliferation, apoptosis and
immune responses L-cysteine is converted to intracellular
gluthathione acting as a scavenger of ROS.
- tocopherol (natural type vitamin E) ...................100mg
