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The Whitening Pills - EstheWhite & EstheShield

EstheWhite

Carotenoids are natural sun protectants found in plants. They absorb harmful UVA and UVB rays and supress free radicals that lead to premature ageing and dark, uneven skin tone. The human body is unable to produce carotenoids, but they can be obtained through diet.




EstheWhite’s key active ingredient, PhytoflORAL® is a patented innovative dietary supplement derived from a proprietary source of non-GMO tomato species that are rich in colourless carotenoids – phytoene and phytofluene. These specific carotenoids are known to lighten and even out skin tone through
  • ·         Inhibition of constitutive melanin synthesis (reduces baseline pigment production)
  • ·         Protection against UVA and UVB rays
  • ·         Significantly increasing anti-inflammatory and anti-oxidant processes

These carotenoids are truly colourless: they do not bleach nor stain the skin

An additional ingredient in EstheWhite is L-Cysteine
It has been shown to prevent the production of darker melanin, stimulate the production of glutathione, promote skin renewal and display anti-oxidant effects


In a clinical study on the effects of colorless carotenoids, clinical scoring by the dermatologist had shown that 60% to 86% of the subjects’ skin quality was significantly improved after 6 weeks and up to 90% of the subjects had improvement in skin dryness, roughness, suppleness, evenness and texture after 12 weeks. The research also showed that after 12 weeks of colorless carotenoids intake, 65% of the subjects‘ skin had a significant 20% increase in the Minimum Erythemal Dose (MED) after UV exposure testing, characterizing a photo-protective effect.

Is It Safe To Take EstheWhite?
EstheWhite is a natural food supplement, that consists of 100% non-GMO, chemically unmodified tomato powder and natural amino acids. There are no known safety concerns, however patients who are allergic or possibly allergic to tomatoes should not take it without consulting their doctor. Pregnant and breastfeeding patients are advised to consult with their obstetricians prior to commencing.

One box of EstheWhite contains 30 capsules
Each EstheWhite capsule contains 500mg of PhytoflORAL, 25mg of L-Cysteine, Cellulose, Silicon Dioxide, and Magnesium Stearate.
Take 1 capsules per day.


EstheShield

Ultimate Systemic Sun Protection
The core ingredient of EstheShield is a proven natural fern extract, polypodium leucotomos. It is an effective chemophoto-protective agent that leads to a significant decrease of UV-induced erythema, sunburn cell formation, DNA damage, epidermal hyperproliferation, and dermal mast cell infiltration.

Polypodium leucotomos has been extensively researched. Clinical studies show that polypodium extracts is effective in defending skin against damage from UV radiation when taken orally. EstheShield is a high potency formulation (500 mg) designed to provide the highest level of protection.
Polypodium leucotomos has both antioxidant and anti-inflammatory properties that help to prevent skin inflammation by inhibiting free radicals in skin tissues from causing long-term DNA damage and photo-ageing.

Is It Safe To Take EstheShield?
EstheShield has been researched for over 40 years, with an excellent safety profile. There are no known contraindications to polypodium leucotomos, however pregnant and breastfeeding patients are advised to consult with their obstetricians prior to commencing.
One box of EstheShield contains 30 capsules
Each EstheShield capsule contains 500mg of Polypodium Leucotomos, Cellulose, Silicon Dioxide, and Magnesium Stearate.
Take 1 capsules per day.


Sun Exposure and Skin Damage
Sun damage may not be visible at an early age, but multiple studies warn of the consequences later in life. Sun exposure damages fibres in the skin called elastin, resulting in skin laxity. UV rays alter the DNA, causing saggy skin, lines, wrinkles, discolouration, age spots, and even cancer.

UV radiation is composed of two different wavelengths, UVA and UVB. When the skin is exposed to UV rays, melanin is photo-oxidised (immediate pigment darkening). This is the process that darkens your skin as it attempts to block out the radiation. Prolonged or repeated exposure to UV radiation results in persistent pigment darkening and eventually long term tanning (delayed tanning) which increases both the amount and activity of melanocytes. The delayed tanning process can last 10 days to several weeks, and with repeated exposure can cause DNA photo-damage.

UVB rays cause sunburn, but it is the UVA rays, with their longer wavelength that penetrate deep into the dermis, that are responsible for photo-ageing of skin. Sensitivity to sunburn is routinely evaluated by minimal erythema dose (MED). MED describes the lowest dose (J/cm2) of UV radiation that will cause erythema assessed 24 hours after exposure. Higher MED means higher tanning capacity. Darker skin is a result of increased number of melanin: it acts a barrier to the UV radiation.

PhytoflORAL
Carotenoids are natural sun protectants found in plants. They absorb harmful UVA and UVB rays and suppress free radicals that lead to premature ageing and dark, uneven skin tone. The human body is unable to produce carotenoids, but they can be obtained through diet.

It has been shown to prevent the production of darker melanin, stimulate the production of glutathione, promote skin renewal and display anti-oxidant effects.

Clinical scoring of the skin quality was significantly improved in 60 to 86% of the panelists after 42 days and in up to 90% of the panelists after 84 days , across all parameters evaluated. Of particular interest, 95% of the subjects had improved skin evenness.

Clinical scoring by the dermatologist presents significant improvement in skin dryness, roughness, suppleness, evenness and texture. Subjective evaluation questionnaire completed by the subjects presents improvement in skin radiance, evenness, hydration, smoothness, suppleness, elasticity and irritability. 

Study subjects found their skin more resistant to sun damage, more beautiful and visibly younger and healthier
Sunlight is a source for external/topical generation of hydroxyl radicals, as was demonstrated by Taira J. et al. This group suggested that sunlight exposure of skin may lead to hydroxyl radical generation and simultaneous lipid peroxidation. Phytoene and phytofluene, the colorless carotenoids are one of the few anti-oxidants that are most effective in quenching of hydroxyl radicals (·OH) and shown in a number of publications.

Polypodium Leucotomos
The core ingredient of EstheShield is a proven natural fern extract, polypodium leucotomos. It is an effective chemophoto-protective agent that leads to a significant decrease of UV-induced erythema, sunburn cell formation, DNA damage, epidermal hyperproliferation, and dermal mast cell infiltration.The core ingredient of EstheShield is a proven natural fern extract, polypodium leucotomos.

Polypodium leucotomos has been extensively researched. Clinical studies show that polypodium extract is effective in defending skin against damage from UV radiation when taken orally. EstheShield is a high potency formulation (500 mg) designed to provide the highest level of protection.

Polypodium leucotomos has both antioxidant and anti-inflammatory properties that help to prevent skin inflammation by inhibiting free radicals in skin tissues from causing long-term DNA damage and photo-ageing.

Overall, 19 human and 6 basic science studies were included in this review spanning over 40 years of research from 1972 to 2014. Oral polypodium leucotomos was administered in daily doses ranging from 120 mg to 1080 mg. This review of literature has demonstrated that PLE is well tolerated at all doses administered.

Current level of evidence suggests that oral PLE is safe and can be prescribed confidently for long term use.
Much of the research that has been done on polypodium leucotomos over the past 40+ years has been on its management of skin conditions and its photo-protective properties after it is ingested. Many of these clinical studies have shown extracts of polypodium leucotomos to be surprisingly effective at defending skin against damage from the sun (ultraviolet radiation) when polypodium leucotomos is taken orally, with some authors even calling it an “internal sunscreen.”

A 2010 publication reported the results of a clinical trial in which 10 healthy volunteers were given either 240mg oral polypodium leucotomos 8 hours and again 2 hours before UVA exposure, or not given anything at all before UVA exposure. Prior to exposure, each individual was measured to determine his or her baseline skin histology and how much UVA radiation it took to cause erythema (MED: minimal erythema dose). After exposure, skin samples were again taken and tested for CD (common deletion: a type of DNA damage and a marker of chronic UVA radiation). At 2 times the MED the non-PL group had increases of CD of 217% over baseline, while the group taking PL had decreases of 84%. At 3 times the MED, the non-PL group had increases of CD of 760% over baseline, while the group taking PL only had a 61% increase on average. These trends were determined “very strong” by the researchers, and while the data was not statistically significant (due in part to the small sample size), the researchers concluded that Polypodium leucotomos “may prevent UVA-induced skin photodamage possibly by preventing UVA-dependent mitochondrial DNA damage.” 

In 2007, a study found that polypodium leucotomos extract was beneficial to individuals who are extremely sensitivity to the sun. The individuals all had either polymorphic light eruption (itchy red rashes from sun exposure) or solar urticaria (a form of hives caused by sunlight), but had not responded well to other available therapies. These patients’ response to sunlight was measured both before and after taking an oral dose of 480 mg of Polypodium leucotomos. The researchers reported that after taking Polypodium leucotomos and being exposed to sunlight, patients had a relevant and statistically significant reduction of skin reactions and subjective symptoms as compared to exposure without PL. The researchers concluded that the “photoprotective activity of Polypodium leucotomos was significant,” and furthermore, the tolerance of PL was excellent and administration was shown to be effective and safe. 

L-Cysteine
Glutathione, the major intracellular reductant, may become rate limiting to cytotoxic lymphocyte activation and proliferation under these circumstances. N-Acetylcysteine (NAC-cys) was used to increase intracellular glutathione levels significant changes in total glutathione (58% increase) at 96 hours. 
Glutathione acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, glutathione has a major role as a protector of biological structures and functions. 
Reactive oxygen species (ROS) are involved in various cellular events including cell proliferation, apoptosis and immune responses  L-cysteine is converted to intracellular gluthathione acting as a scavenger of ROS. 


Disclaimer: Most of the product information from the product website.

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